Improving reproducibility in animal research
نویسندگان
چکیده
منابع مشابه
Reproducibility in research
Progress in biomedical research depends in part on being able to build on the findings of other researchers - and thereby on being able to apply others' methods to your own research. However, most of us have struggled to understand how to repeat or adapt another researcher's study because of minimal or missing details in the Methods section of a published paper. In expensive and complex experim...
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Many factors can influence the outcome and interpretation of experiments using animals – from the strain or sex of the animal through to choosing the correct statistical method for analysis. You would therefore expect such information to be readily available in all publications reporting in vivo research, wouldn’t you? However, this is not the case, according to a recent study published by the ...
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Preclinical animal studies aim to establish safety and efficacy before patients are exposed to new treatments. However, the translational success rate from animal studies to humans is quite low, and the non-reproducibility of preclinical studies ranges between 51% and 89%. The inadequate conduct, reporting, and evaluation of animal research underpinning human trials is one reason why big promis...
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Medical and scientific advances are predicated on new knowledge that is robust and reliable and that serves as a solid foundation on which further advances can be built. In biomedical research, we are in the midst of a revolution with the generation of new data and scientific publications at a previously unprecedented rate. However, unfortunately, there is compelling evidence that the majority ...
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Recent years have seen an increase in alarming signals regarding the lack of replicability in neuroscience, psychology, and other related fields. To avoid a widespread crisis in neuroimaging research and consequent loss of credibility in the public eye, we need to improve how we do science. This article aims to be a practical guide for researchers at any stage of their careers that will help th...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-76398-3